Respiratory organs and the human respiratory system
The last lesson covered plant nutrition; here we see how oxygen enters the human lungs and how blood carries it to every cell.
Blowing on a fire sends air in and out through the airways.
A respiratory surface is where O₂ and CO₂ are exchanged: large area, thin, moist and vascular.
In the figure : Airway and lungs.
Rule 1 : Respiratory organs — Gas exchange is a simple physical process; the surface is large, thin, moist and vascular. Protozoa, sponges: membrane; earthworm, leech, frog: moist skin; insects: spiracles/tracheae; fish: gills; mammals: lungs. Large animals need a circulatory system because diffusion alone is too slow. Plants exchange gases by diffusion through stomata, lenticels and root surfaces.
- Easy : Skin: earthworm.
- Medium : Tracheae: insects.
- Exam-type (CET) : The surface must be moist.
Rule 2 : The human air passage — Nose: vestibule (hairs filter dust), respiratory part (warms and moistens), olfactory part (smell). Pharynx (naso-, oro-, laryngo-) → larynx (voice box; vocal cords; glottis guarded by epiglottis) → trachea (10–12 cm; C-shaped incomplete cartilage rings) → right and left bronchi → bronchioles → alveoli. Lungs: right larger, 3 lobes; left smaller, 2 lobes; double pleura (parietal + visceral) with pleural fluid. About 700 million alveoli; single-layer squamous epithelium. Diaphragm = dome-shaped muscle separating thorax and abdomen.
- Easy : Right lung 3 lobes.
- Medium : Epiglottis = lid.
- Exam-type (CET) : 700 million alveoli.
Right lung has 3 lobes; left has 2.
‘Trachea has complete rings’ is wrong (C-shaped). Trap: ‘alveoli have thick walls’ is wrong.
Memory clue : "NPL-TBBA order of passage".
Spot the difference
| Part | Role |
|---|---|
| Larynx | Voice |
| Trachea | Air passage |
| Alveoli | Gas exchange |
Practice questions
- 1A property of respiratory surface?
- 2Insect respiratory organ?
- 3Length of trachea?
- 4What stops food entering the trachea?
- 5Lobes in left lung?
- 6Number of alveoli?
- 7What is pleura?
- 8Shape of diaphragm?
Show answers (try them yourself first)
- 1Moist, thin, large.
- 2Tracheae / spiracles.
- 310–12 cm.
- 4Epiglottis.
- 52.
- 6~700 million.
- 7Double membrane around lungs.
- 8Dome-shaped.
Mechanism of breathing
Hand on chest while inhaling — it rises forward, then falls.
Breathing = movement of air between atmosphere and lungs (inspiration + expiration). Vital capacity = maximum air breathed out after a maximum inspiration.
In the figure : Breathing and lung volumes.
Rule 1 : Inspiration and expiration — Inspiration (active): diaphragm contracts, flattens and moves down; external intercostal muscles contract, ribs move up and out ⇒ thoracic volume increases, pressure falls ⇒ outside air rushes in. Expiration: diaphragm relaxes and domes up; ribs move down and in ⇒ volume falls, pressure rises ⇒ air leaves. One inspiration + one expiration = one breath. Stages of respiration: breathing, external (alveoli ↔ blood), internal (blood ↔ tissues), cellular.
- Easy : Inspiration: diaphragm flat.
- Medium : Low pressure → air in.
- Exam-type (CET) : Expiration: diaphragm dome.
Rule 2 : Volumes and gas exchange — Tidal volume 500 ml; IRV 2000–3000 ml; ERV 1000–1100 ml; dead space 150 ml; residual volume 1100–1200 ml. Vital capacity = TV + IRV + ERV = 4100–4600 ml (e.g. 500 + 2500 + 1100 = 4100). Total lung capacity = 5200–5800 ml. Diffusion goes from high to low partial pressure: pO₂ alveoli 104, blood 40 mmHg ⇒ O₂ in; pCO₂ blood 45, alveoli 40 mmHg ⇒ CO₂ out. Respiratory membrane = alveolar wall + capillary wall, two thin layers.
- Easy : VC = TV + IRV + ERV.
- Medium : TV = 500 ml.
- Exam-type (CET) : pO₂ in alveoli 104.
VC = TIE: tidal + inspiratory + expiratory reserve.
‘Vital capacity includes residual volume’ is wrong. Trap: ‘diaphragm is flat in expiration’ is wrong.
Memory clue : "In = flat; out = dome".
Spot the difference
| Volume | Value (ml) |
|---|---|
| Tidal | 500 |
| IRV | 2000–3000 |
| ERV | 1000–1100 |
| Residual | 1100–1200 |
Practice questions
- 1Tidal volume?
- 2VC formula?
- 3TV 500, IRV 2500, ERV 1100; VC?
- 4Dead space?
- 5Diaphragm in inspiration?
- 6Alveolar pO₂?
- 7Direction of CO₂ diffusion?
- 8Residual volume?
Show answers (try them yourself first)
- 1500 ml.
- 2TV + IRV + ERV.
- 34100 ml.
- 4150 ml.
- 5Flat, moves down.
- 6104 mmHg.
- 7Blood → alveoli.
- 81100–1200 ml.
Gas transport, regulation and disorders
After running we pant — a rise in blood CO₂ signals the brain.
Oxyhaemoglobin = Hb + O₂. Bohr effect = rise in H⁺, CO₂, temperature shifts Hb towards releasing O₂.
In the figure : Transport of O₂ and CO₂; control.
Gas transport, regulation and disorders
In the app you can move this figure with your finger.
Open in the appRule 1 : Transport of O₂ and CO₂ — O₂: 3% dissolved, 97% on Hb; 1 Hb = 4 O₂ (oxyhaemoglobin); sigmoid curve; 95–97% saturation in alveoli, ~75% in resting tissue (pO₂ 40 mmHg); 50% saturation at ~27 mmHg (P50). Bohr effect: H⁺, pCO₂, temperature ↑ ⇒ curve shifts right ⇒ O₂ released in tissues. CO poisoning: CO binds Hb ~250× more strongly than O₂ ⇒ carboxyhaemoglobin. CO₂: 7% dissolved, ~70% as HCO₃⁻ (carbonic anhydrase in RBC: CO₂ + H₂O ⇄ H₂CO₃ ⇄ H⁺ + HCO₃⁻), ~23% carbaminohaemoglobin. Chloride shift (Hamburger): HCO₃⁻ out, Cl⁻ in. Haldane effect: oxyHb is acidic ⇒ releases CO₂.
- Easy : 97% of O₂ on Hb.
- Medium : 70% of CO₂ = HCO₃⁻.
- Exam-type (CET) : CO: 250× affinity.
Rule 2 : Regulation and disorders — Control: nervous + chemical. Respiratory centres in pons and medulla; adult ~12/min, newborn ~44/min. Hering–Breuer reflex: lung stretch stops inspiration via vagus. Raised CO₂/H⁺ stimulates the centre. Modified movements: cough, sneeze, yawn, sob, laugh. Disorders: emphysema (alveoli break down; smoking), bronchitis, asthma (bronchiole constriction; allergy), pneumonia, silicosis/fibrosis (dust particles). Remedies: stop smoking, masks, antibiotics (bacterial). Artificial ventilation: mouth-to-mouth, ventilator.
- Easy : Pons + medulla = centres.
- Medium : Emphysema: smoking.
- Exam-type (CET) : Asthma: allergy.
O₂ 97% on Hb; CO₂ is 7-70-23 (dissolved - bicarbonate - carbamino).
‘Most CO₂ binds Hb’ is wrong (as HCO₃⁻). Trap: ‘Bohr shift is to the left’ is wrong.
Memory clue : "Bohr = more O₂ released; CO = clings to Hb".
Spot the difference
| Gas | Form | % |
|---|---|---|
| O₂ | On Hb | 97 |
| CO₂ | HCO₃⁻ | ~70 |
| CO₂ | Carbamino-Hb | ~23 |
Practice questions
- 1% of O₂ on Hb?
- 2Carbonic anhydrase is in?
- 3Chloride shift is?
- 4CO affinity vs O₂?
- 5Respiratory centre?
- 6Newborn breaths/min?
- 7Cause of emphysema?
- 8Bohr effect?
Show answers (try them yourself first)
- 197%.
- 2RBCs.
- 3HCO₃⁻ out, Cl⁻ in.
- 4~250 times.
- 5Pons and medulla.
- 6~44.
- 7Smoking / pollution.
- 8More CO₂/H⁺ releases O₂.
Types of circulation and composition of blood
The body's road network — blood carries food, O₂ and wastes.
Blood = fluid connective tissue: plasma (55%) + formed elements. Double circulation = blood passes through the heart twice per cycle.
In the figure : Types of circulation; plasma.
Rule 1 : Types of circulation — Open (insects, molluscs): blood (haemolymph) in cavities; closed (annelids, fish, birds, mammals): in vessels. Closed is of two kinds: single — once through the heart (fish; heart carries only deoxygenated blood = ‘venous heart’); double — twice (birds, mammals): pulmonary (heart → lungs → heart) and systemic (heart → body → heart). Intermediate between tissue and blood = lymph.
- Easy : Fish: single.
- Medium : Birds, humans: double.
- Exam-type (CET) : Pulmonary + systemic.
Rule 2 : Blood and plasma — Blood 4–6 litres; pH 7.4 (alkaline); from mesoderm. Plasma 55%: water 90%, proteins 7–8% (albumin, globulin, prothrombin, fibrinogen), salts 1%, others 1–2% (glucose, amino acids, urea, hormones, enzymes, heparin anticoagulant, antibodies, gases). Serum = plasma − fibrinogen (fluid of clotted blood). Formed elements (~45%): RBC, WBC, platelets. Haematocrit = volume fraction of cells in blood. Study = haematology.
- Easy : Plasma water 90%.
- Medium : Serum = plasma − fibrinogen.
- Exam-type (CET) : pH 7.4.
Plasma = 90 water + 7–8 protein + 1 salt + 1–2 others.
‘Serum contains fibrinogen’ is wrong. Trap: ‘a fish heart pumps oxygenated blood’ is wrong.
Memory clue : "Single = fish; double = mammals".
Spot the difference
| Type | Through heart | Example |
|---|---|---|
| Single | Once | Fish |
| Double | Twice | Human |
Practice questions
- 1Single circulation in?
- 2Two circuits of double circulation?
- 3Open circulation example?
- 4Blood pH?
- 5Plasma percentage?
- 6Water in plasma?
- 7What is serum?
- 8Role of heparin?
Show answers (try them yourself first)
- 1Fish.
- 2Pulmonary + systemic.
- 3Insects.
- 47.4.
- 555%.
- 690%.
- 7Plasma − fibrinogen.
- 8Anticoagulant.
RBC, WBC, platelets and blood groups
After a cut, the bleeding stops once the blood clots.
Erythrocytes (RBC) = red cells with Hb. Leucocytes (WBC) = colourless, nucleated defence cells. Thrombocytes = fragments that clot blood.
In the figure : RBC, WBC, platelets; blood groups.
Rule 1 : RBC and haemoglobin — RBC: circular, biconcave, no nucleus (camel, llama exceptions); men 5.1–5.8, women 4.3–5.2 million/mm³; life 120 days; formation (erythropoiesis) in foetal liver-spleen, adult red bone marrow; needs B₁₂, folic acid, iron; stimulated by erythropoietin (kidney); destroyed in liver, spleen. Hb = 4 globin chains (2α + 2β), each with one haem (iron) ⇒ 4 O₂; men 14–17, women 13–15 g%; anaemia = low RBC/Hb. Breakdown: iron (ferritin), biliverdin → bilirubin (into bile).
- Easy : RBC life = 120 days.
- Medium : Hb carries 4 O₂.
- Exam-type (CET) : Erythropoietin = kidney.
Rule 2 : WBC, platelets, blood groups and clotting — WBC 5000–11000/mm³; amoeboid, diapedesis; <4000 = leucopenia; rise = leucocytosis; uncontrolled = leukaemia. Granulocytes: neutrophil (~70%; phagocytosis; pus), eosinophil, basophil; agranulocytes: lymphocyte, monocyte. Platelets clot blood: injury → platelets + thromboplastin → prothrombin → thrombin → fibrinogen → fibrin mesh → clot. ABO (antigens A, B; Landsteiner): O = universal donor, AB = universal recipient. Rh: Rh⁻ mother with Rh⁺ foetus ⇒ erythroblastosis foetalis.
- Easy : Neutrophils ~70%.
- Medium : Fibrinogen → fibrin.
- Exam-type (CET) : O = universal donor.
Never Let Monkeys Eat Bananas: neutrophil, lymphocyte, monocyte, eosinophil, basophil (by count).
‘Human RBCs have a nucleus’ is wrong. Trap: ‘AB is universal donor’ is wrong (recipient).
Memory clue : "O gives to all; AB receives from all".
Spot the difference
| Cell | Nucleus | Function |
|---|---|---|
| RBC | No | O₂ transport |
| WBC | Yes | Defence |
| Platelets | No | Clotting |
Practice questions
- 1Life of RBC?
- 2RBC formed in?
- 3Erythropoietin from?
- 4O₂ per Hb?
- 5Leucopenia is?
- 6Neutrophil %?
- 7Fibrin forms from?
- 8Universal donor?
Show answers (try them yourself first)
- 1120 days.
- 2Red bone marrow.
- 3Kidney.
- 44.
- 5WBC < 4000.
- 6~70%.
- 7Fibrinogen (by thrombin).
- 8O.
The heart and the cardiac cycle
Listening to a chest you hear ‘lubb-dubb’ — valves closing.
Cardiac cycle = one systole + one diastole (0.8 s). Cardiac output = stroke volume × heart rate.
In the figure : Heart chambers and ECG.
The heart and the cardiac cycle
In the app you can move this figure with your finger.
Open in the appRule 1 : Structure and conduction — Heart: 4 chambers — 2 atria + 2 ventricles; right carries deoxygenated, left oxygenated blood; left ventricle ~3× thicker. Valves: right tricuspid, left bicuspid (mitral); semilunar at aorta/pulmonary artery; Eustachian and Thebesian valves. Conducting tissue: SA node (right atrium; pacemaker) → AV node → bundle of His (two branches) → Purkinje fibres. Control: sympathetic (adrenaline) increases, parasympathetic (acetylcholine) decreases; medulla, hormones.
- Easy : SA node = pacemaker.
- Medium : Left = bicuspid.
- Exam-type (CET) : Left ventricle thickest.
Rule 2 : Cardiac cycle, CO and ECG — Cycle 0.8 s; ~72 beats/min. Atrial systole 0.1 s, atrial diastole 0.7 s; ventricular systole 0.3 s, diastole 0.5 s. In systole AV valves shut ⇒ ‘lubb’; in diastole semilunar valves shut ⇒ ‘dubb’. Joint diastole = all chambers relaxed. Stroke volume ≈ 70 ml; CO = 70 × 72 = 5040 ml ≈ 5 L/min. ECG: P (atrial depolarisation), QRS (ventricular depolarisation), T (ventricular repolarisation). Defective valves cause a ‘heart murmur’.
- Easy : Cycle = 0.8 s.
- Medium : CO = SV × HR.
- Exam-type (CET) : QRS = ventricles.
Lubb = AV valves lock; dubb = semilunar valves.
‘Pacemaker is the AV node’ is wrong (SA node). Trap: ‘tricuspid on the left’ is wrong (bicuspid).
Memory clue : "Right = tricuspid; left = bicuspid".
Spot the difference
| Phase | Time (s) |
|---|---|
| Atrial systole | 0.1 |
| Ventricular systole | 0.3 |
| Joint diastole | 0.4 |
Practice questions
- 1Pacemaker?
- 2Right AV valve?
- 3Cycle duration?
- 4‘Lubb’ occurs when?
- 5SV 70 ml, HR 72; CO?
- 6QRS represents?
- 7Sympathetic effect?
- 8Ventricular systole time?
Show answers (try them yourself first)
- 1SA node.
- 2Tricuspid.
- 30.8 s.
- 4AV valves close.
- 55040 ml/min.
- 6Ventricular depolarisation.
- 7Increases heart rate.
- 80.3 s.
Blood vessels, blood pressure and lymphatic system
Finger on the wrist feels the pulse — an artery's beat.
Blood pressure = force of blood on vessel walls; 120/80 mmHg (systolic/diastolic). Lymph = colourless fluid derived from tissue fluid.
In the figure : Artery, capillary, vein and lymph.
Rule 1 : Vessels and blood pressure — Artery: away from heart; thick elastic wall, narrow lumen; oxygenated blood (exception: pulmonary artery). Vein: towards heart; thin wall, wide lumen, valves; deoxygenated blood (exception: pulmonary vein). Capillary: one cell thick; exchange. Three layers: tunica externa, media, interna. Portal vein: breaks into capillaries again in another organ (liver). BP 120/80 mmHg; <90/60 = hypotension; >140/90 = hypertension. Pulse = arterial beat (radial, carotid).
- Easy : Artery: away; vein: toward.
- Medium : Veins have valves.
- Exam-type (CET) : BP 120/80.
Rule 2 : Heart disorders and the lymphatic system — Atherosclerosis: cholesterol deposits narrow arteries; CAD, angina (chest pain), heart attack (myocardial infarction), hypertension; remedies: diet, exercise, no smoking. Lymphatic system: lymph vessels, lymph nodes, thymus, spleen; lymph is colourless; no RBCs, has lymphocytes; mediates tissue ↔ blood; fat absorption (lacteals); immunity; returns excess tissue fluid to blood.
- Easy : Atherosclerosis = cholesterol.
- Medium : Lymph: no RBCs.
- Exam-type (CET) : Lacteal = fat.
Artery = away; vein = valves, toward heart.
‘All arteries carry oxygenated blood’ is wrong (pulmonary). Trap: ‘lymph has RBCs’ is wrong.
Memory clue : "120/80 = systolic over diastolic".
Spot the difference
| Vessel | Wall | Valves |
|---|---|---|
| Artery | Thick | No |
| Vein | Thin | Yes |
| Capillary | One layer | No |
Practice questions
- 1Artery direction?
- 2What do veins have?
- 3Normal BP?
- 4Hypotension is?
- 5Portal vein feature?
- 6Atherosclerosis cause?
- 7Lacteal absorbs?
- 8Lymph contains?
Show answers (try them yourself first)
- 1Away from heart.
- 2Valves.
- 3120/80 mmHg.
- 4<90/60.
- 5Breaks into capillaries again.
- 6Cholesterol deposits.
- 7Fat.
- 8Lymphocytes; no RBC.
Quick revision of the whole lesson
| Concept | Key fact |
|---|---|
| Air passage | Nose → … → alveoli; 700 million |
| Breathing | VC = TV + IRV + ERV; TV 500 ml |
| Gas transport | O₂ 97% Hb; CO₂ 70% HCO₃⁻ |
| Blood | Plasma 55%; water 90%; pH 7.4 |
| Cells | RBC 120 days; neutrophils 70% |
| Heart | 0.8 s; SV 70; CO 5040 ml |
| Vessels | BP 120/80; veins have valves |
🎯 Most important points for the exam
- Structure of respiratory system.
- Breathing and volumes.
- O₂/CO₂ transport, Bohr effect.
- Circulation and plasma.
- RBC, WBC, blood groups, clotting.
- Cardiac cycle, ECG, CO.
- Vessels, BP, lymph.
Understand the concept → draw the figure → memorise the key points → solve questions yourself.