Drugs: definition, classification and targets
A headache tablet or a fever syrup is a chemical acting at a specific site in the body.
A drug is a chemical giving a biological response in small amounts. Chemotherapy treats disease with chemicals. Classification: by action, chemical structure or molecular target.
In the figure : Main drug classes.
In the figure : Drug and target.
Rule 1: Drug–target interaction — Targets: enzymes or receptors (proteins). Enzyme inhibitors: competitive (block the active site) or allosteric.
- Easy : Competitive: the drug competes with the substrate.
- Medium : Receptor agonist: triggers a response (morphine).
- Exam-type : Antagonist: blocks (ranitidine).
Rule 2: Classes by action — Analgesics, antipyretics, antibiotics, antacids, antihistamines, tranquilisers, antimicrobials, antifertility drugs.
- Easy : Aspirin: pain + fever.
- Medium : Penicillin: bacteria.
- Exam-type : Norethindrone: contraception.
Rule 3: Drug action and safety — Dose matters; too much is toxic; self-medicating with antibiotics builds resistance.
- Easy : Excess paracetamol harms the liver.
- Medium : A half-finished course ⇒ resistant bacteria.
- Exam-type : Not without a doctor's advice.
Reasoning: how does a competitive inhibitor work?
- Step 1: The drug resembles the substrate in shape.
- Step 2: It binds the active site.
- Step 3: The substrate cannot bind ⇒ the reaction slows.
CET level (MCQ)
- CET 1) A receptor is a? 1) carbohydrate 2) protein 3) lipid 4) acid — Answer: 2).
- CET 2) Chemotherapy is? 1) treating disease with chemicals 2) diet 3) surgery 4) yoga — Answer: 1).
Real-life use: Diagnosis, treatment, cancer chemotherapy.
Targets = enzymes/receptors; competitive = active site; agonist activates, antagonist blocks.
Thinking a drug is only a tablet; syrups, injections and ointments count too.
Antibiotics do not work on viruses.
Memory clue: "agonist = on, antagonist = off".
Spot the difference
| Item | Competitive | Allosteric |
|---|---|---|
| Binding | active site | another site |
| Effect | competes | changes shape |
Practice questions
- 1What is a drug?
- 2What is chemotherapy?
- 3Name drug targets.
- 4Explain a competitive inhibitor.
- 5Agonist versus antagonist?
- 6Why is a half course dangerous?
- 7List five drug classes.
- 8Why not antibiotics for viruses?
Show answers (try them yourself first)
- 1A chemical eliciting a biological response.
- 2Treating disease with chemicals.
- 3Enzymes and receptors.
- 4Blocks the active site.
- 5Activates / blocks.
- 6Resistant bacteria.
- 7Analgesic, antipyretic, antibiotic, antacid, tranquiliser.
- 8They act on bacterial structures.
Analgesics, antipyretics and antibiotics
Paracetamol for a headache; antibiotics when a wound turns septic.
Analgesics relieve pain (narcotic: morphine; non-narcotic: aspirin, paracetamol). Antipyretics lower fever. Antibiotics kill or stop bacteria.
In the figure : Preparation of aspirin.
Rule 1: Non-narcotic analgesics — Aspirin (acetylsalicylic acid) inhibits prostaglandin synthesis and thins blood (low dose in heart disease). Paracetamol is gentler on the stomach.
- Easy : Salicylic acid + (CH₃CO)₂O ⇒ aspirin.
- Medium : 13.8 g salicylic acid ⇒ 18 g aspirin (100 %).
- Exam-type : Ibuprofen: anti-inflammatory.
Rule 2: Narcotic analgesics — Morphine and codeine (from opium) for severe pain; addictive and legally controlled.
- Easy : Post-operative pain.
- Medium : Codeine is also in cough syrups.
- Exam-type : Heroin is a derivative (illegal).
Rule 3: Antibiotics — Penicillin (Fleming, 1928), bactericidal or bacteriostatic. Broad spectrum (tetracycline, chloramphenicol); narrow spectrum (penicillin G).
- Easy : Chloramphenicol for typhoid.
- Medium : Ofloxacin: a fluoroquinolone.
- Exam-type : Some people are allergic to penicillin.
Calculation: aspirin from 13.8 g salicylic acid
- Step 1: n = 13.8 ÷ 138 = 0.1 mol.
- Step 2: 1 : 1 ⇒ aspirin = 0.1 mol.
- Step 3: Mass = 0.1 × 180 = 18 g.
CET level (MCQ)
- CET 1) A narcotic analgesic? 1) aspirin 2) paracetamol 3) morphine 4) ibuprofen — Answer: 3).
- CET 2) Penicillin was discovered by? 1) Pasteur 2) Fleming 3) Koch 4) Lister — Answer: 2).
Real-life use: Pain/fever relief, low-dose aspirin as blood thinner, infection treatment.
Aspirin M = 180; paracetamol 151; morphine = narcotic; penicillin = Fleming.
Calling aspirin narcotic; it is non-narcotic.
Antipyretic and analgesic differ, but aspirin is both.
Memory clue: "morphine = narcotic".
Spot the difference
| Drug | Type | Note |
|---|---|---|
| Aspirin | non-narcotic | blood thinner |
| Morphine | narcotic | opium |
| Penicillin | antibiotic | 1928 |
Practice questions
- 1Two types of analgesics.
- 2How is aspirin made?
- 3Source of morphine?
- 4An example of a broad-spectrum antibiotic.
- 5Aspirin from 13.8 g salicylic acid?
- 6Why does aspirin thin blood?
- 7Bactericidal versus bacteriostatic.
- 8How do you avoid resistance?
Show answers (try them yourself first)
- 1Narcotic and non-narcotic.
- 2Salicylic acid + acetic anhydride.
- 3Opium.
- 4Tetracycline.
- 518 g.
- 6It reduces platelet aggregation.
- 7Kills / halts growth.
- 8Complete the course on a doctor's advice.
Antacids, antihistamines and tranquilisers
After spicy food a pinch of soda or milk of magnesia calms heartburn; that is an antacid.
Antacids neutralise excess stomach HCl (pH ≈ 1.5–2). Antihistamines block histamine receptors in allergy. Tranquilisers reduce anxiety and stress.
In the figure : Antacids and HCl neutralisation.
Rule 1: Antacids — NaHCO₃, Mg(OH)₂ and Al(OH)₃ act briefly; ranitidine and cimetidine block H₂ receptors and reduce secretion.
- Easy : Mg(OH)₂ + 2HCl → MgCl₂ + 2H₂O.
- Medium : 1 g Mg(OH)₂ ⇒ 0.0343 mol HCl; 1 g NaHCO₃ ⇒ 0.0119 mol.
- Exam-type : NaHCO₃ gives CO₂ (belching) and can make the stomach alkaline.
Rule 2: Antihistamines — Histamine on H₁ receptors causes allergy (sneezing, itching). Brompheniramine and terfenadine block H₁ but not H₂, so they do not cut acid.
- Easy : Cetirizine for pollen allergy.
- Medium : Drowsiness is a side effect.
- Exam-type : No effect on stomach acid.
Rule 3: Tranquilisers — Equanil, valium and barbiturates (seconal) help anxiety and sleep; antidepressants (iproniazid) treat depression. Never without medical advice.
- Easy : Barbiturates are sleeping pills.
- Medium : Dangerous with alcohol.
- Exam-type : Habit-forming.
Calculation: acid neutralised by 1 g Mg(OH)₂ versus 1 g NaHCO₃
- Step 1: Mg(OH)₂: 1 ÷ 58.3 = 0.01715 mol; 2 HCl ⇒ 0.0343 mol.
- Step 2: NaHCO₃: 1 ÷ 84 = 0.0119 mol; 1 HCl ⇒ 0.0119 mol.
- Step 3: Ratio 0.0343 ÷ 0.0119 ≈ 2.9.
CET level (MCQ)
- CET 1) Acid in the stomach? 1) H₂SO₄ 2) HCl 3) HNO₃ 4) CH₃COOH — Answer: 2).
- CET 2) Which blocks H₂ receptors as an antacid? 1) brompheniramine 2) ranitidine 3) valium 4) morphine — Answer: 2).
Real-life use: Indigestion, allergy, insomnia, anxiety — common health problems.
pH 1.5–2; Mg(OH)₂ ≈ 2.9 × NaHCO₃; H₁ allergy, H₂ acid.
Saying antihistamines reduce stomach acid.
Too much NaHCO₃ can make the stomach alkaline and trigger rebound acid.
Memory clue: "H₁ = allergy, H₂ = acid".
Spot the difference
| Drug | Target | Use |
|---|---|---|
| Ranitidine | H₂ | less acid |
| Brompheniramine | H₁ | allergy |
| Valium | brain | anxiety |
Practice questions
- 1What is an antacid?
- 2Two antacid compounds.
- 3How does ranitidine work?
- 4Why use antihistamines?
- 5What are tranquilisers?
- 6HCl neutralised by 1 g Mg(OH)₂?
- 7What are barbiturates?
- 8Why is excess NaHCO₃ risky?
Show answers (try them yourself first)
- 1A substance neutralising excess stomach acid.
- 2Mg(OH)₂, NaHCO₃.
- 3It blocks H₂ receptors.
- 4To stop allergic reactions.
- 5Drugs reducing anxiety and stress.
- 60.0343 mol.
- 7Sleeping/sedative drugs.
- 8It can make the stomach alkaline with rebound acid.
Antimicrobials and antifertility drugs
Dettol or tincture of iodine on a wound, phenyl on the floor — both kill germs, but for different jobs.
Antimicrobials stop microbial growth. Antiseptics act on living tissue (mild); disinfectants act on non-living objects (strong). Antifertility drugs are hormonal (norethindrone + ethinylestradiol).
In the figure : Use by concentration.
Rule 1: Antiseptics — Phenol 0.2 % is antiseptic, 1 % disinfectant; Dettol = chloroxylenol + terpineol; tincture of iodine 2–3 % (iodine in alcohol); boric acid for eyes.
- Easy : 100 mL of 0.2 % phenol ⇒ 0.2 g phenol.
- Medium : Iodoform on wounds.
- Exam-type : Bithionol in medicated soaps.
Rule 2: Disinfectants — Cl₂ at 0.2–0.4 ppm for drinking water; SO₂ (preservative); 1 % phenol; bleaching powder.
- Easy : For 1 m³ of water, 0.2–0.4 g Cl₂ (ppm = g/m³).
- Medium : Chlorine in swimming pools.
- Exam-type : Ozone also disinfects water.
Rule 3: Antifertility drugs — Norethindrone (progestogen) + ethinylestradiol (oestrogen) stop ovulation (pills).
- Easy : Key ingredient norethindrone.
- Medium : Only on medical advice.
- Exam-type : Hormone-based.
Calculation: Cl₂ for 5 m³ water at 0.2 ppm
- Step 1: 0.2 ppm = 0.2 g per m³.
- Step 2: 5 m³ ⇒ 5 × 0.2 = 1.0 g.
- Step 3: For 0.4 ppm, 2.0 g.
CET level (MCQ)
- CET 1) Phenol 0.2 % is a? 1) disinfectant 2) antiseptic 3) antibiotic 4) tranquiliser — Answer: 2).
- CET 2) Dettol contains? 1) phenol + iodine 2) chloroxylenol + terpineol 3) boric acid 4) KMnO₄ — Answer: 2).
Real-life use: Wound care, water purification, hygiene, family planning.
0.2 % phenol = antiseptic; 1 % = disinfectant; Cl₂ 0.2–0.4 ppm; norethindrone.
Treating antiseptic and disinfectant as the same.
The use changes with phenol strength (0.2 % versus 1 %).
Memory clue: "living = antiseptic, non-living = disinfectant".
Spot the difference
| Item | Antiseptic | Disinfectant |
|---|---|---|
| Applied to | living tissue | objects |
| Phenol | 0.2 % | 1 % |
Practice questions
- 1Antiseptic versus disinfectant.
- 2Two phenol strengths and uses.
- 3Components of Dettol.
- 4What is tincture of iodine?
- 5Cl₂ ppm in water?
- 6Cl₂ for 5 m³ at 0.2 ppm?
- 7Ingredients of birth-control pills.
- 8Phenol in 100 mL of 0.2 % solution?
Show answers (try them yourself first)
- 1Living tissue versus objects.
- 20.2 % antiseptic; 1 % disinfectant.
- 3Chloroxylenol + terpineol.
- 4Iodine in alcohol (2–3 %).
- 50.2–0.4 ppm.
- 61.0 g.
- 7Norethindrone + ethinylestradiol.
- 80.2 g.
Chemicals in food: preservatives, sweeteners, antioxidants
Jam and pickles last for months because of preservatives (salt, sugar, sodium benzoate).
Preservatives stop microbial growth (sodium benzoate, sorbic acid). Artificial sweeteners are low-calorie (saccharin, aspartame). Antioxidants stop fat oxidation (BHT, BHA).
In the figure : Sweetness comparison (log).
Rule 1: Preservatives — Salt, sugar, oil, vinegar (traditional); sodium benzoate, sorbic acid, potassium metabisulphite.
- Easy : Salt and oil in pickles.
- Medium : Sodium benzoate in soft drinks.
- Exam-type : Drying: removing water.
Rule 2: Artificial sweeteners — Versus sucrose: aspartame 100×, saccharin 550×, sucralose 600×, alitame 2000×. For diabetics; aspartame breaks down on cooking; sucralose is stable.
- Easy : Equal to 1 g sugar: saccharin 1/550 g = 1.8 mg.
- Medium : Aspartame: 1/100 g = 10 mg.
- Exam-type : Phenylketonuria patients avoid aspartame.
Rule 3: Antioxidants — BHT and BHA react with oxygen themselves, protecting oils from rancidity; vitamins C and E are natural antioxidants.
- Easy : Rancidity is oxidation.
- Medium : BHA in chip packets.
- Exam-type : Lemon juice keeps cut apple from browning (vitamin C).
Calculation: saccharin matching the sweetness of 1 g sugar
- Step 1: Saccharin is 550 times sweeter.
- Step 2: Needed = 1 g ÷ 550 = 0.00182 g.
- Step 3: = 1.82 mg.
CET level (MCQ)
- CET 1) Sweetest? 1) sucrose 2) aspartame 3) saccharin 4) alitame — Answer: 4).
- CET 2) An antioxidant? 1) BHT 2) saccharin 3) NaCl 4) sorbic acid — Answer: 1).
Real-life use: Sugar-free drinks, jams, pickles, packaged foods.
Sweetness: 100, 550, 600, 2000; aspartame unstable on heating; BHT/BHA = antioxidants.
Treating preservatives and antioxidants as the same.
Saccharin has almost no calories but is not sugar.
Memory clue: "100-550-600-2000" (as-sa-su-al).
Spot the difference
| Substance | Sweetness × |
|---|---|
| aspartame | 100 |
| saccharin | 550 |
| sucralose | 600 |
| alitame | 2000 |
Practice questions
- 1What is a preservative?
- 2Name two artificial sweeteners.
- 3Why is aspartame not used in cooking?
- 4How do antioxidants work?
- 5Saccharin matching 1 g sugar?
- 6Advantage of sucralose.
- 7Name traditional preservatives.
- 8Why does oil turn rancid?
Show answers (try them yourself first)
- 1A substance stopping microbial growth.
- 2Saccharin, aspartame.
- 3It decomposes on heating.
- 4They react with oxygen first.
- 51.82 mg.
- 6Stable on heating.
- 7Salt, sugar, oil.
- 8Because of oxidation.
Soaps and detergents
Soap or detergent washes clothes; soap barely lathers in hard well water.
Soap: fat/oil + NaOH ⇒ sodium salts of fatty acids (saponification). Detergents: synthetic surfactants (sulphates/sulphonates). Both form micelles that carry away grease.
In the figure : Saponification and soap versus detergent.
Rule 1: Saponification — (C₁₇H₃₅COO)₃C₃H₅ + 3NaOH → 3C₁₇H₃₅COONa + C₃H₅(OH)₃. Glycerol is the by-product. KOH gives soft soap.
- Easy : 890 g tristearin ⇒ 918 g soap + 92 g glycerol.
- Medium : 89 g ⇒ 91.8 g soap.
- Exam-type : Coconut oil soap lathers well.
Rule 2: Soap versus detergent — In hard water soap precipitates with Ca²⁺/Mg²⁺ (scum); detergent Ca/Mg salts are soluble ⇒ works in hard water, even in acidic media.
- Easy : 2C₁₇H₃₅COO⁻ + Ca²⁺ → (C₁₇H₃₅COO)₂Ca ↓.
- Medium : Sodium lauryl sulphate (SLS) is a detergent.
- Exam-type : Detergents in shampoos and toothpaste.
Rule 3: Types of detergents and biodegradability — Anionic (SLS), cationic (CTAB, germicidal), non-ionic (liquid detergents). Straight chains are biodegradable; branched are not ⇒ foam pollution.
- Easy : Branched ABS ⇒ foam in rivers.
- Medium : Linear LAS is biodegradable.
- Exam-type : CTAB in conditioners.
Calculation: soap from 89 g tristearin
- Step 1: M(tristearin) = 890 ⇒ 89 g = 0.1 mol.
- Step 2: 1 mol gives 3 mol soap ⇒ 0.3 mol.
- Step 3: M(C₁₇H₃₅COONa) = 306 ⇒ 0.3 × 306 = 91.8 g.
CET level (MCQ)
- CET 1) By-product of saponification? 1) glycerol 2) ethanol 3) CO₂ 4) water — Answer: 1).
- CET 2) Which works in hard water? 1) soap 2) detergent 3) neither 4) NaOH only — Answer: 2).
Real-life use: Laundry, shampoos, dishwashing.
Soap = fatty acid salt + glycerol; detergent works in hard water; straight chain is biodegradable.
Writing that a detergent is a soap; its structure differs (sulphate/sulphonate).
Soap turns into inactive fatty acid in acid; detergents do not.
Memory clue: "soap = scum, detergent = dissolves".
Spot the difference
| Item | Soap | Detergent |
|---|---|---|
| Hard water | scum | works |
| Acidic medium | no | works |
| Biodegradable | yes | depends on chain |
Practice questions
- 1What is saponification?
- 2Why does soap fail in hard water?
- 3Three types of detergents.
- 4Soap from 89 g tristearin?
- 5Which detergent is biodegradable?
- 6How is soft soap made?
- 7Expand SLS.
- 8Use of CTAB?
Show answers (try them yourself first)
- 1Fat + NaOH ⇒ soap + glycerol.
- 2Ca²⁺/Mg²⁺ precipitate.
- 3Anionic, cationic, non-ionic.
- 491.8 g.
- 5The straight-chain one.
- 6Using KOH.
- 7Sodium lauryl sulphate.
- 8Germicide and conditioners.
Safe use of chemicals in daily life
Cleaning chemicals can be dangerous when mixed; reading every label matters.
Chemicals bring benefits and risks; proper dose, storage, mixing rules and environmental care are essential.
Rule 1: Household hazards — Bleach (NaOCl) + acid (toilet cleaner) ⇒ toxic Cl₂; bleach + ammonia ⇒ chloramines.
- Easy : NaOCl + 2HCl → NaCl + Cl₂ + H₂O.
- Medium : Never mix two cleaners.
- Exam-type : Read the warnings on labels.
Rule 2: Safe use of medicines — Correct dose, expiry, medical advice; keep away from children; no expired medicines; finish antibiotic courses.
- Easy : Do not exceed the paracetamol dose.
- Medium : No tranquilisers without a doctor.
- Exam-type : Recheck expiry dates regularly.
Rule 3: Environment — Branched detergents cause foam; plastic waste; water pollution; prefer biodegradable alternatives.
- Easy : Use linear LAS.
- Medium : Recycle plastics.
- Exam-type : Treat wastewater.
Why are bleach + acid dangerous?
- Step 1: NaOCl reacts with acid to give HOCl.
- Step 2: HOCl + HCl → Cl₂ + H₂O.
- Step 3: Cl₂ gas is harmful to breathe.
CET level (MCQ)
- CET 1) Bleach + acid gives? 1) O₂ 2) Cl₂ 3) CO₂ 4) H₂ — Answer: 2).
- CET 2) Biodegradable detergent? 1) branched 2) linear 3) both 4) none — Answer: 2).
Real-life use: Home cleaning, medicine safety, environmental care.
Bleach + acid = Cl₂; linear detergents; medicine dose and expiry.
The misconception that natural means safe.
Mixing two different chemical cleaners.
Memory clue: "read the label, never mix".
Spot the difference
| Unsafe | Safe |
|---|---|
| mixing cleaners | one at a time |
| expired drugs | check expiry |
Practice questions
- 1Why are bleach + acid dangerous?
- 2Two medicine safety rules.
- 3Drawback of branched detergents.
- 4Why complete an antibiotic course?
- 5NaOCl + HCl equation.
- 6How would you cut plastic waste?
- 7Name two household hazards.
- 8What is LAS?
Show answers (try them yourself first)
- 1Toxic Cl₂ forms.
- 2Check dose and expiry.
- 3Not biodegradable; foam.
- 4To avoid resistance.
- 5NaOCl + 2HCl → NaCl + Cl₂ + H₂O.
- 6Recycle and use alternatives.
- 7Bleach + acid; medicines within a child's reach.
- 8Linear alkylbenzene sulphonate.
Quick revision of the whole lesson
| Concept | Key formula / fact |
|---|---|
| Drug | enzyme/receptor target |
| Aspirin | M = 180 |
| Antacid | pH 1.5–2; Mg(OH)₂ |
| Antiseptic | phenol 0.2 % / 1 % |
| Sweeteners | 100 / 550 / 600 / 2000 |
| Soap | fatty acid salt + glycerol |
| Detergent | works in hard water |
| Safety | bleach + acid = Cl₂ |
🚀 Quick revision of the whole lesson
In the app you can move this figure with your finger.
Open in the app🎯 Most important points for the exam
- Drugs and targets.
- Analgesics and antibiotics.
- Antacids, antihistamines, tranquilisers.
- Antimicrobials and antifertility.
- Food chemicals.
- Soaps and detergents.
- Safe use of chemicals.
understand the idea → remember the formula → solve the example → solve problems yourself.